The myelin sheath, which wraps around axons, is crucial for proper nerve conduction. Myelin loss contributes to various neurological disorders, including multiple sclerosis (MS) and neuromyelitis optica (NMO). IPG017 is a novel small molecule antagonist that enhances the differentiation and maturation of oligodendrocyte progenitor cells ( OPCs) into mature oligodendrocytes, promoting myelin regeneration. It holds great potential as a treatment for neuro-demyelinating diseases.
Mechanism of Action
Demyelination disrupts nerve conduction and leads to axonal degeneration, resulting in physical disabilities; IPG017 facilitates the differentiation of OPCs into mature oligodendrocytes, restoring neural myelination and improving overall function.